Yes—coonhounds can make good house dogs for the right home. The American Kennel Club describes coonhound breeds as friendly and easygoing at home, where they often like nothing better than relaxing and spending snuggle time with their owners.
They are still working scent hounds: they need regular mental and physical exercise, have a strong urge to chase small animals, and are known for loud baying. Secure fencing, leash walks, and an experienced owner who will not leave them alone for long stretches make them a much better fit.
Source: Get to Know the Coonhound Breeds of the Hound Group — American Kennel Club