No. Eastern indigo snakes (Drymarchon couperi) are large, nonvenomous snakes of the southeastern United States, and they are not typically aggressive toward people. Official guidance from wildlife agencies describes them as generally inclined to crawl away when disturbed rather than to confront humans.
If cornered, a wild indigo snake may hiss, flatten its neck, or vibrate its tail as a warning. When handled, the species usually calms quickly and rarely bites. Despite that mild demeanor toward people, indigo snakes are powerful predators of other animals—including venomous snakes—and the eastern indigo is federally listed as threatened.