Yes. The Santa Fe Trail ran through Kansas, and about two-thirds of its roughly 750 miles lay in what is now Kansas, according to the Kansas Historical Society.
The trail linked the Missouri River with Santa Fe, then part of Mexico, and also crossed parts of present-day Missouri, Oklahoma, Colorado and New Mexico. William Becknell’s trading party opened the trade in 1821, and the federal government surveyed the route in 1825. Unlike the Oregon-California Trail, which also crossed Kansas but mainly carried settlers, the Santa Fe Trail mostly carried traders, freighters and the military, and it served as a military road during the Mexican War of 1846 to 1848. Its shorter Cimarron cutoff included a 50- to 60-mile stretch that was usually without water in the dry season. Historians count more than 130 trail-related sites along the Kansas portion, including wagon ruts, campgrounds, forts, trading posts, battle sites and burials. The trail’s era ended in 1880, when the Atchison, Topeka & Santa Fe Railway reached Santa Fe.
Source: Kansas Historical Society, “Santa Fe Trail,” Kansapedia
Image: Santa Fe Trail ruts in Ford County, Kansas, by Ammodramus, CC0, via Wikimedia Commons.